evaluation and comparison of urinary cytokines for the diagnosis of acute pyelonephritis

نویسندگان

azar nickavar pediatric nephrology department, aliasghar children’s hospital, iran university medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

baranak safaeian division of pediatric nephrology, neonatal and children’s health research center, golestan university of medical sciences, gorgan, iran; division of pediatric nephrology, neonatal and children’s health research center, golestan university of medical sciences, gorgan, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (golestan university of medical sciences)

ehsan valavi division of nephrology, pediatric department, abuzar children’s hospital, ahvaz university medical sciences, ahvaz, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (ahvaz jundishapur university of medical sciences)

چکیده

results mean urinary il-1α, il-4, il-6, and il-8 concentrations significantly increased in the acute phase of apn compared to the control group, and decreased following antibiotic treatment. conclusions we recommend routine urinalysis and urine culture for the diagnosis of children with apn. urinary il-4 was a relatively good cytokine for the prediction and treatment-monitoring of children with acute febrile uti. methods this multicenter prospective study was performed on 37 (female/male = 6.5:1) children with symptomatic culture-proven apn and 37 (female/male = 1.6/1) age-matched febrile children without utis as the control group. urine samples were obtained before antibiotic treatment in both groups and 3 - 4 days after treatment in the uti group, and evaluated for interleukin (il)-1α, il-1β, il-2, il-4, il-6, il-8, il-10, tumor necrosis factor-α (tnfα), monocyte chemoattractant protein-1 (mcp-1), and vascular endothelial growth factor (vegf) using an elisa immunoassay kit. objectives the aim of this study was to identify and compare the diagnostic and therapeutic implications of recently introduced cytokines for the diagnosis of acute pyelonephritis (apn). background the accurate diagnosis and management of febrile urinary tract infection (uti) is a clinical challenge in the absence of specific clinical and laboratory findings in infants and young children.

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عنوان ژورنال:
archives of pediatric infectious diseases

جلد ۴، شماره ۴، صفحات ۰-۰

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